This blog post discusses the limitations of Python as a programming language for data science, focusing on specific language features that hinder its effectiveness. Key points include Python's call-by-reference semantics, lack of ...
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Claus Wilke is a biology professor and researcher interested in science, AI, communication, and data visualization, writing a popular newsletter on these topics.
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The post discusses the limitations of AI in programming and computational biology, particularly in the context of using tools like Claude Sonnet and BindCraft for tasks such as peptide binder design. The author shares personal exp...
The post discusses the importance of understanding random number generation in data analysis and machine learning, particularly the implications of using a fixed random seed like 42. The author argues that relying on a specific se...
The post discusses the common practice of using the random seed '42' in programming, particularly in machine learning and data analysis. The author argues that this choice is problematic because it leads to repeated results and hi...
The article critiques a previous claim that obtaining a PhD is easy, arguing instead that it is a challenging and individualized process. The author, a PhD holder and advisor, emphasizes the importance of mentorship, the variabili...
The blog post provides guidance for undergraduates and first-year graduate students in the US on how to write a compelling personal statement for the NSF Graduate Research Fellowship Program (GRFP). It emphasizes the importance of...
The author reflects on their education in math and physics in Germany and contrasts it with their experiences in the US. They discuss the concept of bicycle stability, explaining that it is related to the conservation of angular m...
The post discusses essential abilities and character traits necessary for success in a PhD program, arguing that these qualities are often more important than intelligence. Key traits include executive function, fearlessness, ment...
5.6Sociopathic AI agents
2026-02-15 • technology ethics empathy antisocial behavior ai
The post warns about the rise of sociopathic AI agents mimicking harmful human behaviors and stresses the importance of developing empathic AI for better alignment with human values.
The author critiques Python as a programming language for data science, arguing that it is often cumbersome and less efficient than R for various data analysis tasks. Drawing from personal experiences in a computational biology la...
The post discusses the paradox of large language models (LLMs) being both effective and ineffective at programming. It highlights two distinct skillsets in programming: deep reasoning about algorithms and memorization of documenta...
The article critiques a Substack post claiming civilization is in decline due to screens and cell phones, arguing that while literacy may be changing, it doesn't necessarily indicate a decline in civilization. The author highlight...
This blog post provides guidance on writing a research plan for the NSF Graduate Research Fellowship Program (GRFP). It emphasizes the importance of creating a concise outline rather than a detailed plan, and suggests using resour...
The blog post discusses the common issue of PhD students proposing overly ambitious thesis projects that are unrealistic given their time constraints. It argues that while some professors may exploit students for labor, many gradu...
The author, a data visualization instructor, expresses concern over the impact of generative AI on teaching and assessing student learning. With students able to complete data analysis projects quickly using AI tools like ChatGPT,...
The blog post critiques the common recommendation of 'Strunk and White' for improving writing, suggesting that many people either haven't read it or lack alternative suggestions. The author presents their favorite writing books, f...
The post compiles feedback on executive function, particularly in relation to ADHD. It includes personal experiences from individuals with ADHD, highlighting challenges such as procrastination, fear of failure, and the need for en...
The author expresses frustration with the prevalence of subscription models in various aspects of life, particularly criticizing platforms like Substack for their dark patterns that manipulate users into subscribing. They argue th...
The post discusses executive function, a set of mental skills crucial for organizing tasks, managing time, and achieving goals. It defines executive function as the brain's management system, highlighting key components like worki...
The author critiques the viability of 3D-printed houses as a solution to rising housing costs, based on personal observations of construction in Austin. Key points include the slow printing process, limited construction capabiliti...
The author, Claus Wilke, celebrates reaching 1000 subscribers on Substack after four months. He shares demographic insights about his subscribers, noting a balanced distribution between the US and other countries, with specific st...