The blog post discusses the development and market dynamics of FGF21 analogs for treating non-alcoholic steatohepatitis (NASH). It highlights Bristol Myers Squibb's discontinuation of pegbelfermin in 2021 despite its initial promi...
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Alex Kesin is a biotech analyst and blogger passionate about enhancing healthy lifespan and enjoys biking and films.
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The post explores how the character Walter White from 'Breaking Bad' would fare in terms of cancer treatment and health insurance if the show were set in 2025. It discusses advancements in cancer therapy, particularly targeted tre...
The blog post discusses Eli Hurvitz's unconventional journey from a dishwasher to the CEO of Teva Pharmaceuticals, highlighting his unique approach to business and risk management. It explores his early life, the founding of Assia...
Axiom Bio aims to revolutionize drug safety predictions by using AI and human liver cells to better assess liver toxicity, moving beyond traditional animal testing methods.
The article discusses the legal battle between Amgen and Regeneron over the patents for PCSK9 inhibitors, specifically evolocumab and alirocumab. Amgen claimed broad patent rights over any antibody that could bind to PCSK9, despit...
The article recounts the story of Mark Fishman, a Harvard cardiologist hired by Novartis in 2002 to lead its research and development efforts despite lacking pharmaceutical experience. Under his leadership, the Novartis Institutes...
6.3July in Israel
2025-07-25 • travel israel war cultural experience
The author recounts their first trip to Israel during a time of conflict, highlighting the juxtaposition of ordinary life amidst war. They share experiences with locals, including a Navy reservist, a tank driver, and various trave...
The text discusses the unethical practices of Hims & Hers Health, a company that exploits regulatory loopholes to profit from selling drugs for sexual dysfunction, hair loss, and obesity. The company's business model involves char...
The text argues against the opposition to life extension, stating that longevity is ethically imperative and economically rational. It refutes the physiological and sociopolitical arguments against longevity, highlighting the succ...
The text describes the author's experience working in biotech in San Francisco, contrasting the biotech industry with the software industry. The author discusses the challenges and cognitive dissonance of working in biotech in a c...
0Still Here, Still Jewish
2025-05-22 •
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The letter urges the Secretary of Health and Human Services to reclassify low-dose statins from prescription-only to over-the-counter, citing evidence of their safety and effectiveness in preventing cardiovascular disease. The aut...
Dr. Marty Makary, a transplant surgeon and the commissioner of the Food and Drug Administration, is playing poker at a saloon. He has made significant changes at the FDA, including firing the vaccine czar and cutting 3,500 positio...
The text describes a conference on aging research where speakers present complex jargon to discuss aging interventions. The author criticizes the lack of ambition and the focus on incremental progress, highlighting the fear and de...
The text compares the pharmaceutical industry to Hollywood, highlighting the similarities in their narrative-driven nature and the pursuit of one-off dreams. It discusses the sacrifices and efforts involved in drug discovery and t...
The FDA's new guidelines plan to phase out preclinical animal studies for monoclonal antibody BLAs, causing Charles River Laboratories' stock to crash. The company, heavily reliant on animal testing, is facing financial and struct...
The text discusses the cultural significance of skiing in San Francisco, emphasizing that it is not just a vacation activity but a way of life and a status symbol.
The FDA has announced a roadmap to phase out animal testing for monoclonal antibodies and other drugs, citing the lack of predictive value in animal models and the stress on animals. The roadmap includes the use of New Approach Me...
The text discusses the effectiveness and relevance of the National Institutes of Health (NIH) in the modern world, highlighting the challenges and contradictions it faces in funding and supporting scientific research and innovatio...
China's pharmaceutical industry has experienced a surprising ascent, transitioning from a supporting player to a major leader in drug innovation. The country now hosts world-class R&D hubs, produces novel drugs approved internatio...
The text discusses six proposals to improve the FDA's drug development process, including adopting a Clinical Trial Notification model, greater use of international trial standards, genetic priority designation, sharing non-sensit...
The text discusses how individuals have used narrow leverage to gain power and influence, using examples such as Paul Atreides, Trump, Carl Icahn, Napoleon, and others. It also explores the concepts of capital transcending origins...
0Prescription strength: musings about the past/present/future of sarcopenia therapeutics
2025-01-09 • challenges bodybuilding effectiveness safety drug development pharmacotherapy sarcopenia anabolic-androgenic steroids selective androgen receptor modulators myostatin inhibitors apj receptor agonists pparδ
Sarcopenia is a progressive, chronic age-related loss of muscle mass and function that affects millions of older adults worldwide. Despite the clear unmet need, there are still no FDA-approved pharmacological therapies for sarcope...
0Anti-Amyloids and Antichrist
2026-02-02 •
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