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Nicholas Reville is the author of Recursive Adaptation, a Substack publication focused on breakthrough science and strategy for addiction and mental health. The site offers completely free subscriptions and has thousands of subscribers.

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The proposal for an NIH High-Leverage Trials Program aims to facilitate large-scale trials for off-patent drugs and supplements, unlocking new treatments and cost savings.
CASPR is advocating for next-generation addiction medicine amidst budget cuts to federal agencies like NIDA, NIAAA, and SAMHSA. The FDA's new National Priority Voucher (NPV) program could expedite drug approvals for addiction trea...
Apple and Google should remove online gambling apps from their stores to protect users from addiction and reduce their liability in related lawsuits.
The author evaluates their 2025 addiction predictions, highlighting successes and failures in treatment advancements and trends in overdose deaths.
The blog post discusses the rapid expansion of legal sports betting in the U.S. following the Supreme Court's decision to end the national ban. It highlights the significant revenue generated by the industry, the addictive nature ...
Suzetrigine's approval offers a chance to significantly reduce opioid prescriptions and addiction rates, but affordability and access remain major challenges.
Natasha Schull explores the connection between gambling addiction and design, advocating for ethical interventions and regulatory measures to mitigate the issue.
The blog post discusses the rapid growth of the sports betting industry in the U.S. following the Supreme Court's 2018 decision to legalize it in many states. It highlights the shift from traditional sportsbooks to online betting ...
CASPR's Life Savings program reveals the dangers of online gambling, ranking states on their policies and advocating for protective measures against addiction and financial loss.
The article discusses the Open Doors / CASPR program, SheThrives, which provides GLP-1 medications to women with a history of substance use disorder in post-incarceration housing. It highlights the success of participants like Jes...
The article discusses the recent indictment of two MLB players for accepting bribes to manipulate game actions, highlighting the dangers of 'prop bets' in sports gambling. Prop bets, which focus on specific actions during games, a...
CASPR is initiating a program to combat online gambling addiction, emphasizing preventive policies during an upcoming briefing for state legislators.
The rise of online gambling has led to addiction issues, prompting CASPR to launch a program aimed at consumer protections and state policy evaluations.
The Washington Post featured an article on CASPR's GLP-1 pilot programs for substance use disorder (SUD) at Caron in PA/FL and OpenDoors in RI, which are reportedly the only two such programs globally. The article highlights the p...
A recent Gallup poll indicates a significant decline in alcohol consumption among Americans, with only 54% reporting they drink. This trend aligns with industry sales reports and suggests a long-term decrease in drinking among you...
The article discusses Dr. Steve Klein's innovative program at Caron Treatment Center, which utilizes semaglutide, a GLP-1 medication, to treat patients with addictions rather than for obesity or diabetes. Funded by CASPR, the prog...
CASPR is hiring for three positions to enhance its research and policy efforts in health and addiction sectors.
Join the CASPR event on January 13, 2026, to discuss GLP-1 pilot programs and policy strategies for addiction reduction with expert panelists.
The author is heading to CPDD in New Orleans for an addiction conference. They express disappointment at the lack of GLP-1 related presentations and mention their upcoming attendance at BIO in Boston. They also mention the cancell...
The text discusses the potential of GLP-1 drugs to revolutionize addiction treatment, highlighting the massive impact of addiction, the high probability of success of GLP-1s, and the potential for permanent societal change. It als...
The BRIDGE Initiative at Caron Treatment Centers has launched a program offering direct access to GLP-1 receptor agonists for individuals undergoing residential treatment for substance use disorders. The program has already enroll...
Nicholas Reville is looking for a documentary film producer to follow a pilot project providing semaglutide in a polysubstance post-incarceration female population and track recidivism. He also discusses the use of semaglutide for...
Drew, an administrative assistant, shares her experience with GLP-1s, which helped decrease her alcohol consumption and shopping urges. She tried various methods to quit drinking, but only GLP-1s worked. She noticed a decrease in ...
The text discusses various topics related to addiction, including the potential use of GLP-1RAs like Ozempic for addiction, the need for FDA reform, the impact of cannabis use disorder and vaping on public health, and the importan...